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Upon intravenous injection into the tail vein, the nanoparticles selectively accumulated in the tumor of the animal model

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Integration of local IGF-I/IGF-IR signaling with systemic hormones Integration with GH Although it is well established that GH stimulates hepatic gene expression to make and supply IGF-I to the circulation, recent studies suggest that changes in circulating IGF-I levels may be an indicator of GH status, but may not be directly involved in controlling local functions in non-hepatic tissues, including bone (68)

doi: 144

TFR1, Transferrin receptor 1

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