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This receptor difference explains why Melanotan 1 vs 2 have different roles in research

A 2007 study in Chemical Research in Toxicology observed that the free GHK tripeptide quenched 4-hydroxy-trans-2-nonenal a cytotoxic lipid-peroxidation aldehyde via Michael addition at the histidine and lysine side chains, contributing one route to the broader antioxidant profile attributed to the compound (PMID 17672515)

They were then treated with non-toxic doses (1, 10, 100, 1000 M) of standards and UDE containing -EC at 0.1, 1, 10, and 100 M for 4 h

It has no meaningful parallel to clinician-supervised TRT aimed at restoring normal hormone levels

As we get older, we get sick more often and it's more severe