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In type 2 diabetes mellitus, portal vein insulin levels are elevated to compensate for the insulin-resistant state of the body
A limitation of the current review is that it focused on indirect comparisons of 24-h continuous monitoring studies that differed in terms of study population (e.g., obese or not-obese, ambulatory or not-ambulatory), study treatment (e.g., continuous intravenous infusion, or oral administration) and timing of assessment after variable duration of study treatment
These are usually reserved for people who need more immediate results or have more persistent skin conditions, like hyperpigmentation and melasma
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doi: 10.1016/S0140-6736(12)60479-6 40 BergenstalRMWyshamCMacconellLMalloyJWalshBYanPet al
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