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Certain factors might preclude the use of semaglutide, such as a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2, alongside a history of pancreatitis or severe gastrointestinal conditions

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As a secondary end-point, a direct comparison with liraglutide (up to 1.8 mg) was made

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Available data with tirzepatide in pregnant patients are insufficient to evaluate for a drug-related risk of major birth defects, miscarriage, or other adverse maternal or fetal outcomes

Patients should check blood glucose levels more frequently than usual, and healthcare providers should consider reassessing hemoglobin A1c within 3 months