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10.2353/ajpath.2006.050617 17 FisherE

Its ability to cross the bloodbrain barrier in laboratory models, combined with a relatively long plasma half-life compared to other small neuropeptides, has contributed to its enduring relevance in neurochemistry research

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Clinically depressed patients reportedly have impaired glutamatergic and hyperactive acetylcholine systems, whereas they have a dramatically suppressed gamma-aminobutyric acid (GABA) system (Pytka et al., 2016