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NADH inhibits all regulatory enzymes of the cycle, and ATP serves as a metabolic inhibitor for pyruvate dehydrogenase and isocitrate dehydrogenase complexes

10.1038/nature13148 95 MaoC.LiuX.ZhangY.LeiG.YanY.LeeH.et al (2021)

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If not effective, non-oral therapies such as levodopa-carbidopa intestinal gel (LCIG) delivered continuously through a percutaneous endoscopic gastro-jejunal (PEG-J) tube, or deep brain stimulation, represent the alternative [24]

doi:10.1093/ajcn/77.1.189 Rafighi Z, Shiva A, Arab S, Mohd Yousof R