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Patients with a history of severe allergic reactions to Tirzepatide should avoid using Zepbound(8 Trusted Source Tirzepatide: Overview Go to source)
Less common but more serious concerns include gallbladder disease, pancreatitis and kidney injury associated with dehydration
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Mech Ageing Dev 2000;120:1419
Trials such as the STEP 2 and SURMOUNT 3 programs have consistently shown average weight loss of ~1520% of baseline body weight compared to placebo over long-term treatment periods
And, when the V max values are set to 10% of their normal values, the number of functional hepatocytes decreases to 10% of normal after 40 hours (the red curve), well below the grey bar marking 30% remaining hepatocytes, which is thought to be the threshold for liver failure[10]
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