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They warn that the lack of rigorous clinical trials and standardized protocols raise serious safety concerns, including the risk of hepatotoxicity (liver damage caused by chemicals) and allergic reactions like anaphylaxis

Standard community-protocol cycles run 4-6 weeks on with 2-4 weeks off

Armstrong MJ, Gaunt P, Aithal GP, Barton D, Hull D, Parker R, et al

95% CI = 1.254.09), but was lost in those MDS that used folic acid supplements at peri-conception (OR = 1.07

Reduced SAM-to-SAH Ratio A low ratio suggests less effective methylation potential even when a single SAM value appears adequate