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The amylin pathway works through a distinct mechanism from incretin-based agents: amylin, co-secreted with insulin by pancreatic beta cells, slows gastric emptying, suppresses postprandial glucagon, and acts on the area postrema in the brain to reduce food intake complementary rather than overlapping with GLP-1 receptor signaling

Int J Biochem Cell Biol 42 : 425428

Some compounding pharmacies have included it in formulations, which the FDA has flagged

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Semaglutide also slows gastric emptying, which means food stays in your stomach longer after meals