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Retatrutide adds glucagon receptor agonism, which may further reduce visceral adiposity compared with GLP-1 single agonism, potentially amplifying androgenic benefit

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In clinical trials, severe reactions were reported in 1.7% of patients using 5 mg, 2.5% with 10 mg, and 3.1% with 15 mg, compared to only 1% for placebo

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Blood pressure and heart rate should be checked at each dose escalation

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