Animal experiments have shown that rats treated with IGF-1 LR3 (0.3 mg/kg/d) for 8 consecutive weeks have a 2-fold increase in fasting insulin levels and a 1.8-fold increase in HOMA-IR index
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This usually subsides as the body adjusts, and adequate hydration paradoxically helps reduce retention
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Lee PR, Cohen JE, Tendi EA, Farrer R, GH DEV, Becker KG, et al