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Mitochondrial complex II has a key role in mitochondrial-derived reactive oxygen species influence on plant stress gene regulation and defense
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In accordance, SGLT2i inhibit renal glucose reabsorption, ameliorating blood glucose levels with additional effects on body weight and blood pressure, leading to improved renal and CV outcomes in subjects with T2DM, especially heart failure and kidney failure [126-131]
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Non-synonymous changes are nucleotide codon changes that alter the amino acid coded at the protein level, while synonymous changes alter the nucleotide while preserving the amino acid
"A novel single nucleotide polymorphism in the 3' untranslated region of human glutathione peroxidase 4 influences lipoxygenase metabolism"
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