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To mitigate risks, the authors recommend pairing GLP-1 therapy with resistance training and high-protein diets proven strategies to maintain muscle during weight loss
5.17 Single-cell RNA sequencing and data visualization The single-cell RNA sequencing dataset comprising intestinal epithelial cells from the terminal ileum and colon of healthy donors as well as inflamed and non-inflamed tissues from Crohns disease patients was obtained from the Human Cell Atlas portal ( and initially published by Kong et al
Among the 534 patients receiving semaglutide, 62.9% achieved MASH resolution without worsening fibrosis compared with 34.3% in the placebo group
By year four, the treatment difference had narrowed from peak values
For patients using licensed injectable GLP-1 receptor agonists who have concerns about their treatment, contact your GP or diabetes care team for advice
Checking for ketones may be appropriate in some situations
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