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Widespread use of DOACs began in 2010 due to multiple factors, including 421 : Standardized dosing Decreased frequency of follow-ups Less adverse effects Fewer medication and food interactions Quicker onset of action Because of these factors, DOACs are generally preferred over warfarin by both patients and physicians

but exogenous estrogen replacement in post-menopausal women was found to have several adverse side effects, therefore this treatment is not recommended (Rajfer et al

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Step 3: Prepare the injection site Choose your injection site: stomach, thigh, or upper arm