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Makris, K
Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity
GERD (acid reflux): This is also more common with semaglutide, affecting 11% of people compared to 6% with tirzepatide
Other common gastrointestinal effects include: Diarrhea Constipation Abdominal pain or cramping Bloating and gas Acid reflux or heartburn Decreased appetite (this is both a therapeutic effect and a side effect) Most of these effects are transient
Here is what the research shows
In this situation, most providers would recommend skipping or delaying that weeks dose until the acute illness resolves, then resuming the normal schedule
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