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However, semaglutide's liver effects are largely indirect, mediated through weight loss and improved metabolic parameters rather than direct hepatic lipid oxidation

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Collectively, our results and existing literature support the long-term feasibility of arGLP-1 therapy when side effects are proactively managed

Additionally, semaglutide treatment protected synaptic plasticity and reversed the hippocampal neuroinflammation induced by HFD fed, improving activation of the insulin pathway, demonstrating the protective effects of semaglutide

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