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The patient profiles that favor each Zepbound fits best when: Maximum weight loss is the priority (BMI 35+ or significant metabolic complications) The patient tolerates injections without significant aversion Insurance coverage or self-pay program access is reasonable The patient has not responded to lower-efficacy alternatives Orforglipron will fit best when: Needle aversion has prevented or threatened to derail injectable therapy Mild-to-moderate obesity where ~14% weight loss is sufficient Frequent travel makes cold-chain storage impractical Daily oral routine is more sustainable than weekly injection ritual A small percentage of patients clearly fit one bucket
The titration schedule exists for a reason
Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity
Regardless of the prescribing route, patients with ADHD require careful assessment and ongoing monitoring
[Crossref] [PubMed] Mollan SP, Tahrani AA, Sinclair AJ
I've been prescribing GLP-1 medications since 2015, starting with exenatide and moving through every generation of these therapies
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