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The most common adverse effects are gastrointestinal, including nausea, vomiting, diarrhea, constipation, and abdominal discomfort
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These local effects are generally mild and transient, resolving within minutes to hours after administration
Precise targeting of miRNA sites restores CFTR activity in CF bronchial epithelial cells
IPRA and PIO significantly improved hepatocellular hypertrophy, micro-vesicular steatosis, lobular inflammation and mild fibrosis in a dose-dependent manner, with the activities of PIO being weaker compared to those of IPRA
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