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Curcumin ((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) activates and desensitizes the nociceptor ion channel TRPA1
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10.1016/j.cyto.2008.10.012 148
Early Human Data (Limited) A small number of exploratory human studies have examined: gastrointestinal-related applications (BPC-157) inflammation or tissue-response markers in specific controlled settings These studies generally involve small sample sizes and limited endpoints
So, Zepbound works in the gut like the bodys natural GLP-1 and GIP
In the SURMOUNT-1 trial, 24-26% of participants experienced nausea at some point during the study, most commonly during dose escalation phases
The B6 in Brello formulation may provide some relief, though many users report nausea regardless
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