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Does Incretin Agonism Have Sustainable Efficacy

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Unlike natural GLP-1, which breaks down in 1-2 minutes, the modified peptide has a longer half-life, ranging from hours to days

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4.1.3 Diabetes mellitus link to epilepsy Diabetes mellitus associated with epilepsy involves multiple molecular mechanisms

The appetite-suppressing effect of GLP-1 is mediated by its action in the brain, whereas its glucose-lowering effect is mainly attributed to enhancement of glucose-stimulated insulin secretion [74]