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GSH is synthesized from cysteine, glutamate, and glycine by the ATP-dependent enzyme -glutamyl-cysteine (-GC) ligase (GCL) synthetase, which is composed of the -GC ligase catalytic subunit (GCLC), the -GC modifier subunit (GCLM), and GSH synthetase (GSS) 24
A recent genetic screen of genes complementing the loss of GPx4 in resistant cell lines uncovered new players for ferroptosis inhibition
The role of iron homeostasis in remodeling immune function and regulating inflammatory disease
The following section describes and summarizes these drugs in terms of the mechanisms by which they activate the GSH system (Table 3, Supplementary Table S3)
IGF-1 alleviates ox-LDL-induced inflammation via reducing HMGB1 release in HAECs [PMID: 22782142] Laboratory literature summary: IGF-1 alleviates ox-LDL-induced inflammation via reducing HMGB1 release in HAECs
Baseline characteristics are shown in Table 4
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