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Neuronal ferroptosis directly contributes to hippocampal atrophy and neuronal loss in the prefrontal cortex, manifesting as cognitive deficits, impaired spatial learning and memory, and mood dysregulation (Dang et al., 2022

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Third, it upregulates VEGFR2 and activates the VEGFR2-Akt-eNOS pathway, accelerating blood vessel formation and blood flow recovery in ischaemic tissue, a mechanism confirmed in endothelial cell culture and rat hind-limb ischaemia models by Hsieh 2017

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