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Albogami Y, Cusi K, Daniels MJ, Wei YJ, Winterstein AG

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AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons

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The other main roles of arhalofenate are to activate AMPK, inhibit NF-B and NLRP3 inflammasomes to promote the polarisation of anti-inflammatory macrophages, as well as significantly reduce UA-induced inflammation (Salminen et al., 2011