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[5] Dabigatran (Pradaxa) Dabigatran, a direct thrombin inhibitor, was the first DOAC approved for AF (FDA, 2010)
Acta Paediatr (1997) 86(2):1549
Myeloid-derived suppressor cells (MDSCs), a distinct subset of immunosuppressive cells abundant in the hypoxic TME, diminish the activation of CD8 + T lymphocytes through the secretion of the inhibitory cytokines IL-10 and IL-6
The short-term cost tsunami easily dwarfs any savings, adding that attributing improvements to a specific therapy is inherently difficult outside controlled clinical trials
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