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I was among the people who thought five years ago therell never be small molecules here There are GLP-1 receptors and a second source of GLP-1 within the brain, completely isolated from the peripheral system and Trapp has shown that stimulating these receptors can have an even greater impact on weight loss in animal studies

2003 Feb;17(2):161-71

Garg SK et al

References Lederer DJ, Longo DL, Martinez FJ