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In 2023, Lopez-Otin proposed twelve markers of aging, including genomic instability, telomere loss, epigenetic changes, loss of protein balance, failure of macroautophagy, dysregulated nutrient sensing, mitochondrial dysfunction, cell senescence, stem cell depletion, altered intercellular communication, chronic inflammation, and dysbiosis
To maintain data integrity for each subject, a single random time interval was generated, and then used to shift all the dates for the same subject
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Headaches and Dizziness: These effects can occur, particularly during the initial phase of therapy
V., Hannon B
