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Its effects require intact amylin receptor signaling, as demonstrated in receptor knockout models where weight loss is abolished, and structural studies show unique conformational dynamics at these receptors compared to native amylin or other analogs
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A unique characteristic of presence of catalytic cysteine in the active site help them in thioltransferase activity instead of GSH transfer activity
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Trialkyl phosphorothioates and glutathione S-transferases [PMID: 4028290] Laboratory literature summary: Trialkyl phosphorothioates and glutathione S-transferases
L.KimK.-W.et al (2020)
