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A few milestones worth knowing: 2021: Semaglutide 2.4 mg injection (Wegovy) was approved by the US FDA for weight management in June 2021
The CV benefits of the SGLT2 inhibitor on HF and CV death (primarily driven by HF) are observed with months and most likely are hemodynamically driven (simultaneous reduction in preload and afterload), while those of GLP-1s on MACE take 12 to 16 months to be seen and most likely are related to the drugs antiatherogenic effects
A self-insured employer or health plan that currently doesnt cover the new weight loss medications needs to make sure that their PBM holds the line
Carnitine has been shown in studies to enhance muscle building by increasing androgen receptors in muscle cells
In a model of non-ischemic HF in dogs (tachycardiomyopathy induced by pacemakers), IV infusion of GLP-1 increases left ventricular (LV) contractility (LV dP/dt increased by 98%, stroke volume by 102%, and cardiac output by 57%) and decreases LV end-diastolic pressure, heart rate, and systemic vascular resistance
Beyond glucose control, semaglutide activates neural pathways that influence mood, motivation, and metabolic stress responses
