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doi:10.1155/2012/723419 76

Mitochondrial unfolded protein response gene Clpp is required to maintain ovarian follicular reserve during aging, for oocyte competence, and development of pre-implantation embryos

Combined, these effects might intensify but can be managed through careful monitoring and support from healthcare providers

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Glutamate excitotoxicity disrupts synaptic transmission and increases intracellular calcium levels, triggering a cascade of neurotoxic effects

While an increase in metformin exposure was observed, it was not considered clinically relevant by the investigators