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At this point, GPX1 surprisingly appears to enhance the initial inflammatory response by initiating the production of pro-inflammatory cytokines to enhance the LPS-induced inflammatory response (Lubos et al., 2010)

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Furthermore, after ingestion of Pycnogenol , taxifolin, catechin, caffeic acid, ferulic acid and metabolite 1 [-(3,4-dihydroxy-phenyl)--valerolactone] have been detected in the blood plasma of volunteers (8)