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Both drugs appear to dampen the mesolimbic dopaminergic reward pathway, which is why many patients describe reduced cravings for alcohol, sweets, and ultra-processed food within the first month

Phentermine triggers a norepinephrine release that suppresses appetite

Also, many people with diabetes take medications to treat other chronic conditions such as cardiovascular disease (CVD)

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That matters because the field's dominant strategy for the last decade has been additive more receptors, more signal, more weight loss