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In patients with epilepsy treated with VPA, the levels of plasma metabolites such as triglycerides, sphingomyelin, phosphorylcholine, ceramides, and phenolic phthiocerols were significantly increased, and the levels of phosphoethanolamines, diacylglycerols, 1,25-dihydroxy-24-oxo-22-oxavitamin D3, 2-deoxy-20-hydroxy-5alpha-ecdysone 3-acetate, and dolichyl-4 phosphate were significantly decreased (28)