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Nociceptive signaling is primarily conveyed by extrinsic afferent fibers innervating the intestinal muscularis, where transient receptor potential vanilloid 1 (TRPV1)-expressing nociceptors are abundantly localized 106

2), further confirming flavan-3,3,4-triol ( 4 ) as the oxidation product of LDOX from 3,4- cis -leucocyanidin ( 6 )