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The Cochrane database of systematic reviews , (12), CD007769

bioRxiv2026 Jan 9

Leveraging the University of California Health Data Warehouse enabled a realworld analysis of 6,871 patients with primary colon cancer and rigorous adjustment strategies to probe whether GLP1 RA exposure relates to fiveyear mortality. At the end of the study, researchers found that participants with colon cancer taking GLP-1 medications had a 15.5% mortality risk within 5 years, compared to 37.1% in participants not taking the drugs

Beyond the FDAs list, one case report linked melanotan II to rapid breakdown of muscle tissue

95% CI, 0.96-3.85, respectively)

Combining Medication with Lifestyle Changes Weight loss medications work best when combined with lifestyle modifications