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Mast cell activation may facilitate the entry of pathogenic antibodies into the CNS by disrupting the blood-brain barrier and attracting additional immune cells into neural tissue
The following are known triggers of mast cell degranulation (in addition to IgG activation via pathogen or allergen):[ref] Acetylcholine Complement fragments (C3, C4, C5) Various drugs, environmental toxins (MRGPRX2 receptor, details below) Peptides (including endorphin, leptin, PTH, and more) Physical conditions (cold, heat, pressure, stress, and vibration)
doi: 10.1007/978-3-211-73574-9_14 106 JianXZhaoGChenHWangYLiJXieLet al
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