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349 Similarly, mutations in valosin-containing protein (VCP), a multifunctional AAA-ATPase essential for extracting ubiquitinated proteins from cellular structures and directing them toward degradation, cause multisystem proteinopathies that include ALS, FTD, and inclusion body myopathy

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Patients with pre-existing diabetic retinopathy should be monitored closely, as rapid improvements in glycemic control have been associated with temporary worsening of retinopathy in some patients