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The nuclear factor erythroid 2-related factor 2 ( NFE2L2 or NRF2) transcription factor is constitutively activated in many cancers and promotes a specific gene expression program involved in cellular detoxification, redox buffering, and metabolic rewiring (Cancer Genome Atlas Research, 2012

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Statements Author contributions TS, CK, and CS all contributed to the design, writing, and editing of the manuscript

An adverse event linked to one product may reflect a formulation problem rather than an intrinsic property of GHK-Cu