Androgen stimulation could also explain the accentuated smooth muscle elements often found in the dermis of Becker melanosis
This is covered in more detail in the contraindications section below
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Cluster analyses have suggested that only a subset of patients with OSA may be at major cardiometabolic risk, and thus, randomized controlled trials may need to identify high risk patients a priori rather than the typical one-size-fits-all approach 21,22