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50.5% of patients achieved 15% or more weight loss

Treatment with 8 mg ribupatide injection weekly in a randomized, double-blind, placebo-controlled Phase 2 trial conducted in China resulted in 23.6% weight loss from baseline compared to 1.7% for placebo at Week 36 when analyzed using the efficacy estimand with no observed weight loss plateau, indicating further weight loss may be possible with longer treatment duration

No difference between smokers and nonsmokers regarding supplemental and dietary intakes of antioxidant micronutrients, including selenium, was found to contribute to the association of smoking and rectal cancer (68)

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