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[9] Visual disturbances have been reported in patients with Leber hereditary optic neuropathy, and rapid B12 administration may precipitate optic nerve atrophy in this genetically predisposed population, mandating extreme caution or alternative therapy

The NICE guidelines on obesity management do not include B12 supplementation as a therapeutic option for weight reduction in the absence of documented deficiency

A deficiency of Vitamin B12 can lead to advanced anemia where the red cells are fewer in number but are larger than normal (macrocytic)

Analytical identification and characterisation

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