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Metabolism The metabolism of common GLP-1 RAs varies across agents: Exenatide undergoes hydrolysis in the kidneys and liver, producing smaller inactive peptides excreted via the kidneys (23)
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Synthetic GLP-1 receptor agonists are long acting with a 13 hour half-life and have been shown to improve glycemic control and aid in weight loss
Lower concentrations mean larger injection volumes, which can be easier to measure accurately with standard insulin syringes
Westerman, Sue
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