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Sabah AA, Fletcher C, Webbe G, Doenhoff MJ (1986) Schistosoma mansoni: Chemotherapy of infections of different ages

Clinical reviews have shown that this transmucosal route successfully bypasses the destructive enzymes of the GI tract and the liver's first-pass metabolism, resulting in a rapid and statistically significant increase in blood GSH concentrations

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In this way, the experimental data is condensed and replicates are replaced by single time courses for dynamic modeling