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While both are effective for weight management, their specific approvals from the FDA point to some key differences

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Cao S, Pan Y, Tang J, Terker AS, Arroyo Ornelas JP, Jin G-N, Wang Y, Niu A, Fan X, Wang S

Rybelsus is oral semaglutide, which requires a different formulation (the peptide is co-formulated with the absorption enhancer SNAC to survive gastric acid)