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Mechanism of Action: DSIP acts on the central nervous system, helping to modulate sleep-wake cycles, particularly enhancing deep (delta) sleep

Finally, the results of one randomized controlled trial in 601 patients with common forms of retinitis pigmentosa indicated that supplementation with 400 IU/day of synthetic vitamin E (equivalent to 180 mg/day of RRR --tocopherol) modestly but significantly accelerated the loss of retinal function compared to placebo (123)

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The trial was not powered for cardiovascular outcomes