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In a mouse model of osteoporosis, treatment with MOTS-c improved bone density and microarchitecture, implying that it helped reverse bone loss or accelerate bone regeneration

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Activation, Differential Localization, and Regulation of the Stress-Activated Protein Kinases, Extracellular Signal-Regulated Kinase, C-JUN N-Terminal Kinase, and P38 Mitogen-Activated Protein Kinase, in Synovial Tissue and Cells in Rheumatoid Arthritis

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