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Despite this promise, several critical limitations remain: No large-scale, randomized controlled human trials to confirm efficacy, safety, or long-term impact Toxicology and pharmacokinetic data are lacking, especially for chronic use or high-dose regimens Only one stereoisomer (all-L form) has been tested

However, clinically significant improvements in overall glycemic control should not be expected during the initial month, as this dose is primarily intended for gastrointestinal adaptation rather than maximal therapeutic effect

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OShea JJ, Schwartz DM, Villarino AV et al (2015) The JAK-STAT pathway: impact on human disease and therapeutic intervention

March 26, 2024