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This reaction takes place in the mitochondrial matrix and is catalyzed by carnitine acyltransferase 2 (also called carnitine palmitoyltransferase 2, CPT2), which is located on the inner face of the inner mitochondrial membrane

Neurological Relevance Preclinical evidence suggests broader neuroprotective potential: In traumatic brain injury models, SS-31 reduced mitochondrial swelling, neuronal loss, and neuroinflammation Aged mice treated with SS-31 showed significantly improved exercise tolerance, muscle strength, and mitochondrial efficiency Studies demonstrate protection against ischemic injury and enhanced cardiac output Phase 3 trials are ongoing for dry age-related macular degeneration and primary mitochondrial myopathy (Stealth BioTherapeutics pipeline) Implications for Brain Aging Mitochondrial dysfunction is a hallmark of brain aging and neurodegeneration

Key takeaways The votes recommend adding these peptides to the Section 503A Bulks List, which is a permission to compound, not a finding that the drugs work

The California BOP has not offered any scientific or safety-based explanation for why this widely used and celebrated treatment should be restricted

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doi: 10.1016/j.rbmo.2020.01.026 222 PlacidiMDi EmidioGVirmaniADAlfonsoAArtiniPGDAlessandroAMet al