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Anyone who is pregnant, planning a pregnancy, or breastfeeding should seek medical advice and avoid investigational medicines unless specifically directed by a clinician

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The FDA has expressed concerns about compounded versions, noting they "received multiple reports of adverse events, some requiring hospitalization, that may be related to dosing errors associated with compounded injectable semaglutide products." However, many patients used compounded versions successfully under proper medical supervision.

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In a July 2024 retrospective, electronic health record (EHR) study in 41,222 adults with overweight or obesity treated for type 2 diabetes, 81.8% of people receiving tirzepatide (Mounjaro) lost at least 5% of their weight within one year compared to 66.5% of those using semaglutide (Ozempic), a significant difference (which means it did not just happen by chance)

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