While preparing this manuscript for submission, a study based exclusively in in vitro assays was published showing that the addition of 25 M BSO or the use of tools to delete GCLC inhibits the growth of Burkitt lymphoma cell lines under 2D culture conditions [42], seemingly suggesting a comparable susceptibility to glutathione starvation between TICs and differentiated tumor cells
Free radicals are unstable molecules that can lead to oxidative stress and contribute to various chronic diseases, such as heart disease, cancer, and certain neurological disorders
Though squalane is often called an oil, its technically not one
Ethics declarations The FR/FMG lab receives additional grant support from AstraZeneca, Eli Lilly and LGC for unrelated work
4,5 Dietary insufficiency, pernicious anemia (i.e., an autoimmune process that reduces available intrinsic factor and subsequent absorption of vitamin B 12 1,2,6,7 ), and long-term use of metformin or acid-suppressing medications have been implicated in B 12 deficiency
IV infusions or IM injection absorption is 100% FAST AND EFFECTIVE