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Marcello M, Virz GM, Marturano D, de Cal M, Marchionna N, Sgarabotto L, et al
32,33 Moreover, immune checkpoint upregulation (PD-1, CTLA-4, TIGIT, LAG-3) and suppressive signaling cascades such as PTEN lossPI3K/AKT hyperactivation exacerbate T-cell dysfunction and resistance to ICIs
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